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Article

Targeted next-generation sequencing reveals multiple deleterious variants in OPLL-associated genes.

Scientific reports - 1 Jun 2016

Chen Xin, Guo Jun, Cai Tao, Zhang Fengshan, Pan Shengfa, Zhang Li, Wang Shaobo, Zhou Feifei, Diao Yinze, Zhao Yanbin, Chen Zhen, Liu Xiaoguang, Chen Zhongqiang, Liu Zhongjun, Sun Yu, Du Jie

Abstract excerpt

Ossification of the posterior longitudinal ligament of the spine (OPLL), which is characterized by ectopic bone formation in the spinal ligaments, can cause spinal-cord compression. To date, at least 11 susceptibility genes have been genetically linked to OPLL. In order to identify potential deleterious alleles in these OPLL-associated genes, we designed a capture array encompassing all coding regions of the...

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Identifiers

PMID: 27246988
DOI: 10.1038/srep26962
PMCID: PMC4887887

Genes

BMP2
FGFR1
MAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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