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Article

RUNX2 polymorphisms associated with OPLL and OLF in the Han population.

Clinical orthopaedics and related research - 1 Dec 2010

Liu Yang, Zhao Yongfei, Chen Yu, Shi Guodong, Yuan Wen

Abstract excerpt

BACKGROUND: Runt-related transcription factor 2 (RUNX2), BMP-2, COL6A1, and VDR are four genes that may be related to ossification of the spinal ligament. However, their pathogenetic relevance remains unclear. Most cases of ossification of the posterior longitudinal ligament (OPLL) and ossification of the ligamentum flavum (OLF) have been reported in Asian populations, but the polymorphic loci in these genes may...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20721706
DOI: 10.1007/s11999-010-1511-5
PMCID: PMC2974870

Genes

RUNX2
VDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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RUNX2 polymorphisms associated with OPLL and OLF in the Han population.PMID 20721706Read ↗

COL6A1 polymorphisms associated with ossification of the ligamentum flavum and ossification of the posterior longitudinal ligament.Semantic proximity Read ↗

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Association Study of Fibroblast Growth Factor 2 and Fibroblast Growth Factor Receptors Gene Polymorphism in Korean Ossification of the Posterior Longitudinal Ligament PatientsSemantic proximity Read ↗

A new haplotype in BMP4 implicated in ossification of the posterior longitudinal ligament (OPLL) in a Chinese population.Semantic proximity Read ↗

Targeted next-generation sequencing reveals multiple deleterious variants in OPLL-associated genes.Semantic proximity Read ↗

Genomewide linkage and linkage disequilibrium analyses identify COL6A1, on chromosome 21, as the locus for ossification of the posterior longitudinal ligament of the spine.Semantic proximity Read ↗

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A genome-wide association study identifies susceptibility loci for ossification of the posterior longitudinal ligament of the spine.Semantic proximity Read ↗

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