Article
[Genomic analysis of ossification of the posterior longitudinal ligament].
Clinical calcium - 1 Apr 2016
Tsuji Takashi
Abstract excerpt
OPLL is considered as a multi-factorial disease influenced by genetic and environmental factors. To identify genetic factors for OPLL, Genetic Study Group of Investigation Committee on Ossification of the Spinal Ligament performed a genome-wide association study(GWAS)using 1,660 OPLL patients. The study group identified six susceptibility loci for OPLL:20p12.3(rs2423294:P= 1.10 × 10(-13)), 8q23.1(rs374810:P= 1.88...
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