Article
A genome-wide association study identifies susceptibility loci for ossification of the posterior longitudinal ligament of the spine.
Nature genetics - 1 Sept 2014
Nakajima Masahiro, Takahashi Atsushi, Tsuji Takashi, Karasugi Tatsuki, Baba Hisatoshi, Uchida Kenzo, Kawabata Shigenori, Okawa Atsushi, Shindo Shigeo, Takeuchi Kazuhiro, Taniguchi Yuki, Maeda Shingo, Kashii Masafumi, Seichi Atsushi, Nakajima Hideaki, Kawaguchi Yoshiharu, Fujibayashi Shunsuke, Takahata Masahiko, Tanaka Toshihiro, Watanabe Kei, Kida Kazunobu, Kanchiku Tsukasa, Ito Zenya, Mori Kanji, Kaito Takashi, Kobayashi Sho, Yamada Kei, Takahashi Masahito, Chiba Kazuhiro, Matsumoto Morio, Furukawa Ken-Ichi, Kubo Michiaki, Toyama Yoshiaki, Ikegawa Shiro
Abstract excerpt
Ossification of the posterior longitudinal ligament of the spine (OPLL) is a common spinal disorder among the elderly that causes myelopathy and radiculopathy. To identify genetic factors for OPLL, we performed a genome-wide association study (GWAS) in ∼8,000 individuals followed by a replication study using an additional ∼7,000 individuals. We identified six susceptibility loci for OPLL: 20p12.3 (rs2423294: P =...
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