Article
Genomewide linkage and linkage disequilibrium analyses identify COL6A1, on chromosome 21, as the locus for ossification of the posterior longitudinal ligament of the spine.
American journal of human genetics - 1 Oct 2003
Tanaka Toshihiro, Ikari Katsunori, Furushima Kozo, Okada Akihiro, Tanaka Hiroshi, Furukawa Ken-Ichi, Yoshida Kenichi, Ikeda Toshiyuki, Ikegawa Shiro, Hunt Steven C, Takeda Jun, Toh Satoshi, Harata Seiko, Nakajima Toshiaki, Inoue Ituro
Abstract excerpt
Ossification of the posterior longitudinal ligament (OPLL) of the spine is a subset of "bone-forming" diseases, characterized by ectopic ossification in the spinal ligaments. OPLL is a common disorder among elderly populations in eastern Asia and is the leading cause of spinal myelopathy in Japan. We performed a genomewide linkage study with 142 affected sib pairs, to identify genetic loci related to OPLL. In...
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