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Article

A new haplotype in BMP4 implicated in ossification of the posterior longitudinal ligament (OPLL) in a Chinese population.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 May 2012

Ren Yuan, Feng Jie, Liu Zhi-zhong, Wan Hong, Li Jun-hua, Lin Xin

Abstract excerpt

Previous genome-wide microarray analysis of candidate genes involved in the ossification of the posterior longitudinal ligament (OPLL) of the spine resulted in the identification of a novel, clinically relevant gene encoding bone morphogenetic protein 4 (BMP4) but was defined only by its expression patterns. The complete genomic BMP4 coding DNA from 450 patients with OPLL and 550 matched controls were sequenced...

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Identifiers

PMID: 22052794
DOI: 10.1002/jor.21586

Genes

BMP4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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