Identification of susceptibility loci for thoracic ossification of the posterior longitudinal ligament by whole-genome sequencing.

doi:10.3892/mmr.2017.8171

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Article

Identification of susceptibility loci for thoracic ossification of the posterior longitudinal ligament by whole-genome sequencing.

Molecular medicine reports - 1 Feb 2018

Wang Peng, Liu Xiao, Zhu Bin, Ma Yunlong, Yong Lei, Teng Ze, Wang Yongqiang, Liang Chen, He Guanping, Liu Xiaoguang

Abstract excerpt

Ossification of the posterior longitudinal ligament (OPLL) is a myelopathy commonly observed in the cervical spine. By contrast, thoracic OPLL (T‑OPLL) is rare but more severe. Previous studies have identified several polymorphisms in osteogenic genes that are associated with the occurrence and development of cervical OPLL. However, few genetic studies have evaluated T‑OPLL. The present study aimed to identify...

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PMID: 29207129
DOI: 10.3892/mmr.2017.8171

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