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Article

A cell culture system for distinguishing hepatitis C viruses with and without liver cancer-related mutations in the viral core gene.

Journal of hepatology - 1 Dec 2015

El-Shamy Ahmed, Eng Francis J, Doyle Erin H, Klepper Arielle L, Sun Xiaochen, Sangiovanni Angelo, Iavarone Massimo, Colombo Massimo, Schwartz Robert E, Hoshida Yujin, Branch Andrea D

Abstract excerpt

BACKGROUND & AIMS: Although patients infected by genotype 1b hepatitis C virus (HCV) with Q(70) and/or M(91)core gene mutations have an almost five-fold increased risk of developing hepatocellular carcinoma (HCC) and increased insulin resistance, the absence of a suitable experimental system has precluded direct experimentation on the effects of these mutations on cellular gene expression. METHODS: HuH7 cells...

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Share to Carcinoma, Hepatocellular
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Viral

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Source

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Identifiers

PMID: 26220749
DOI: 10.1016/j.jhep.2015.07.024
PMCID: PMC4654634

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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