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Article

Toxoplasma ROP16I/III ameliorated inflammatory bowel diseases via inducing M2 phenotype of macrophages.

World journal of gastroenterology - 7 Dec 2019

Xu Yong-Wei, Xing Rui-Xin, Zhang Wen-Hui, Li Lu, Wu Yi, Hu Jing, Wang Cong, Luo Qing-Li, Shen Ji-Long, Chen Xi

Abstract excerpt

BACKGROUND: Inflammatory bowel disease (IBD) is characterized by chronic and non-specific inflammation of the intestinal mucosa and mainly includes ulcerative colitis and Crohn's disease. AIM: To explore the beneficial effect of ToxoROP16I/III-induced M2 phynotype macrophages in homeostasis of IBDs through downregulation of M1 inflammatory cells. METHODS: RAW264.7 macrophages stimulated by lipopolysaccharide...

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Identifiers

PMID: 31832003
DOI: 10.3748/wjg.v25.i45.6634
PMCID: PMC6906210

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