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Article

Paraoxonases-1, -2 and -3: What are their functions?

Chemico-biological interactions - 25 Nov 2016

Furlong Clement E, Marsillach Judit, Jarvik Gail P, Costa Lucio G

Abstract excerpt

Paraoxonase-1 (PON1), an esterase/lactonase primarily associated with plasma high-density lipoprotein (HDL), was the first member of this family of enzymes to be characterized. Its name was derived from its ability to hydrolyze paraoxon, the toxic metabolite of the insecticide parathion. Related enzymes PON2 and PON3 were named from their evolutionary relationship with PON1. Mice with each PON gene knocked out...

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Source

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Identifiers

PMID: 27238723
DOI: 10.1016/j.cbi.2016.05.036
PMCID: PMC5391248

Genes

PON1
PON2
PON3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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