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Article

Paraoxonases: ancient substrate hunters and their evolving role in ischemic heart disease.

Advances in clinical chemistry - 1 Jan 2013

Martinelli Nicola, Consoli Letizia, Girelli Domenico, Grison Elisa, Corrocher Roberto, Olivieri Oliviero

Abstract excerpt

Interest in the role of paraoxonases (PON) in cardiovascular research has increased substantially over the past two decades. These multifaceted and pleiotropic enzymes are encoded by three highly conserved genes (PON1, PON2, and PON3) located on chromosome 7q21.3-22.1. Phylogenetic analysis suggests that PON2 is the ancient gene from which PON1 and PON3 arose via gene duplication. Although PON are primarily...

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Source

Identifiers

PMID: 23461133
DOI: 10.1016/b978-0-12-405211-6.00003-6

Genes

PON1
PON2
PON3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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