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Article

Targeting stroma and tumor, silencing galectin 1 treats orthotopic mouse hepatocellular carcinoma

21 Oct 2023

Abstract excerpt

This study examines inhibiting galectin 1 (Gal1) as a treatment option for hepatocellular carcinoma (HCC). Gal1 has immunosuppressive and cancer-promoting roles. Our data showed that Gal1 was highly expressed in human and mouse HCC. The levels of Gal1 positively correlated with the stages of human HCC and negatively with survival. The roles of Gal1 in HCC were studied using overexpression (OE) or silencing using...

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PMID: 38261802
DOI: 10.1016/j.apsb.2023.10.010

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