Article
Truncated CD200 stimulates tumor immunity leading to fewer lung metastases in a novel Wistar rat metastasis model.
Biochemical and biophysical research communications - 5 Feb 2018
Kuwabara Jun, Umakoshi Akihiro, Abe Naoki, Sumida Yutaro, Ohsumi Shota, Usa Eika, Taguchi Kana, Choudhury Mohammed E, Yano Hajime, Matsumoto Shirabe, Kunieda Takeharu, Takahashi Hisaaki, Yorozuya Toshihiro, Watanabe Yuji, Tanaka Junya
Abstract excerpt
CD200 mediates immunosuppression in immune cells that express its receptor, CD200R. There are two CD200 variants; truncated CD200 that lacks the part of N-terminal sequence necessary for CD200R binding (CD200S) and full-length CD200 (CD200L). We established a novel lung metastasis model by subcutaneously transplanting C6 glioma cells into the backs of neonatal Wistar rats. All transplanted rats developed large...
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