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Article

Genetic insights into carbohydrate sulfotransferase 8 and its impact on the immunotherapy efficacy of cancer

30 Dec 2023

Abstract excerpt

Immune checkpoint blockade (ICB) is a promising therapy for solid tumors, but its effectiveness depends on biomarkers that are not precise. Here, we utilized genome-wide association study to investigate the association between genetic variants and tumor mutation burden to interpret ICB response. We identified 16 variants (p < 5 × 10 −8 ) probed to 17 genes on 9 chromosomes. Subsequent analysis of one of the most...

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PMID: 38165805
DOI: 10.1016/j.celrep.2023.113641

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