Article
Impairment of DNA Methylation Maintenance Is the Main Cause of Global Demethylation in Naive Embryonic Stem Cells.
Molecular cell - 16 Jun 2016
von Meyenn Ferdinand, Iurlaro Mario, Habibi Ehsan, Liu Ning Qing, Salehzadeh-Yazdi Ali, Santos Fátima, Petrini Edoardo, Milagre Inês, Yu Miao, Xie Zhenqing, Kroeze Leonie I, Nesterova Tatyana B, Jansen Joop H, Xie Hehuang, He Chuan, Reik Wolf, Stunnenberg Hendrik G
Abstract excerpt
Global demethylation is part of a conserved program of epigenetic reprogramming to naive pluripotency. The transition from primed hypermethylated embryonic stem cells (ESCs) to naive hypomethylated ones (serum-to-2i) is a valuable model system for epigenetic reprogramming. We present a mathematical model, which accurately predicts global DNA demethylation kinetics. Experimentally, we show that the main drivers of...
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