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Article

The angiopietin-1-Tie2 pathway prevents rather than promotes pulmonary arterial hypertension in transgenic mice.

The Journal of experimental medicine - 28 Sept 2009

Kugathasan Lakshmi, Ray Julie Basu, Deng Yupu, Rezaei Effat, Dumont Daniel J, Stewart Duncan J

Abstract excerpt

The role of the angiopoietin-1 (Ang1)-Tie2 pathway in the pathogenesis of pulmonary arterial hypertension (PAH) is controversial. Although Ang1 is well known to prevent endothelial activation and injury in systemic vascular beds, this pathway has been suggested to mediate pulmonary vascular remod...

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Source

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Identifiers

PMID: 19737862
DOI: 10.1084/jem.20090389
PMCID: PMC2757882

Genes

PAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19737862-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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