Article

Angiopoietin-like protein 2 mediates vasculopathy driven fibrogenesis in a mouse model of systemic sclerosis

2023-10-19

Abstract excerpt

<h4>ABSTRACT</h4> Vasculopathy is a common hallmark of various fibrotic disorders including systemic sclerosis (SSc), yet its underlying etiology and contribution to fibrogenesis remain ill-defined. In SSc the vasculopathy typically precedes the onset of fibrosis and we observed that this phenomenon is recapitulated in the Snail transgenic mouse model of SSc. The vascular anomalies manifest as deformed vessels, e...

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Literature Corpus work: 1a966cc5-c024-5ce8-89ff-76d528655fd8
DOI: 10.1101/2023.10.16.562467

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