Article

Prevention of toxic epidermal necrolysis by regulatory T cells

2005-05-24

Abstract excerpt

To analyze immunoregulation of autoreactive T cells specific for epidermal skin antigens, we crossed transgenic mice expressing ovalbumin selectively in keratinocytes under the keratin 5 promoter (K5-mOVA) with mice expressing a Kb-restricted OVA-specific T cell receptor transgene (OT-I). In athymic double-transgenic mice, OT-I cells developed extrathymically and, at 8–12 weeks of age, initiated severe epidermal d...

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Literature Corpus work: 485865f8-35c2-5094-a4fc-55e78ac86f4c
DOI: 10.1002/eji.200425773

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