Article
Roots and stems: stem cells in cancer.
Nature medicine - 1 Mar 2006
Polyak Kornelia, Hahn William C
Abstract excerpt
Cancer develops from normal tissues through the accumulation of genetic alterations that act in concert to confer malignant phenotypes. Although we have now identified some of the genes that when mutated initiate tumor formation and drive cancer progression, the identity of the cell population(s) susceptible to such transforming events remains undefined for the majority of human cancers. Recent work indicates...
Topics
- Cell Transformation, Neoplastic
- Humans
- Models, Biological
- Mutation
- Neoplasms
- Neoplastic Stem Cells