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Article

HBM Mice Have Altered Bone Matrix Composition and Improved Material Toughness.

Calcified tissue international - 1 Oct 2016

Ross Ryan D, Mashiatulla Maleeha, Acerbo Alvin S, Almer Jonathan D, Miller Lisa M, Johnson Mark L, Sumner D Rick

Abstract excerpt

The G171V mutation in the low-density lipoprotein receptor-related protein 5 (LRP5) leads to a high bone mass (HBM) phenotype. Studies using HBM transgenic mouse models have consistently found increased bone mass and whole-bone strength, but little attention has been paid to the composition of the bone matrix. The current study sought to determine if the cortical bone matrix composition differs in HBM and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27230741
DOI: 10.1007/s00223-016-0154-2
PMCID: PMC7376697

Genes

HBM
LRP5

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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