Article
Alterations to the Gut Microbiome Impair Bone Strength and Tissue Material Properties.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jun 2017
Guss Jason D, Horsfield Michael W, Fontenele Fernanda F, Sandoval Taylor N, Luna Marysol, Apoorva Fnu, Lima Svetlana F, Bicalho Rodrigo C, Singh Ankur, Ley Ruth E, van der Meulen Marjolein Ch, Goldring Steven R, Hernandez Christopher J
Abstract excerpt
Alterations in the gut microbiome have been associated with changes in bone mass and microstructure, but the effects of the microbiome on bone biomechanical properties are not known. Here we examined bone strength under two conditions of altered microbiota: (1) an inbred mouse strain known to develop an altered gut microbiome due to deficits in the immune system (the Toll-like receptor 5-deficient mouse...
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