Article
Genetic variation in mouse femoral tissue-level mineral content underlies differences in whole bone mechanical properties.
Cells, tissues, organs - 1 Jan 2009
Courtland Hayden-William, Spevak Mila, Boskey Adele L, Jepsen Karl J
Abstract excerpt
A/J mice, as compared to C57BL/6J (B6) mice, have a significantly greater total femoral mineral (ash) content which correlates with an increased femoral stiffness (resistance to deformation), but also with an increased brittleness (catastrophic failure). To determine if this whole bone variation in mineral content is indicative of significant mineral and/or matrix variation at the tissue level, femora from...
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