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Article

High-amplitude theta wave bursts characterizing narcoleptic mice and patients are also produced by histamine deficiency in mice.

Journal of sleep research - 1 Oct 2016

Bastianini Stefano, Lo Martire Viviana, Berteotti Chiara, Silvani Alessandro, Ohtsu Hiroshi, Lin Jian-Sheng, Zoccoli Giovanna

Abstract excerpt

Histamine and orexins are wake promoters released by hypothalamic neurons. The activity of histamine neurons is increased by orexin neurons. Recently, it has been shown that orexin deficiency entails high-amplitude theta wave bursts during rapid eye movement sleep and cataplexy in narcoleptic mice. The primary aim of this study was to assess whether histamine system is involved in high-amplitude theta wave burst...

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PMID: 27230703
DOI: 10.1111/jsr.12404

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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