Article
Histidine decarboxylase deficiency causes tourette syndrome: parallel findings in humans and mice.
Neuron - 8 Jan 2014
Baldan Lissandra Castellan, Williams Kyle A, Gallezot Jean-Dominique, Pogorelov Vladimir, Rapanelli Maximiliano, Crowley Michael, Anderson George M, Loring Erin, Gorczyca Roxanne, Billingslea Eileen, Wasylink Suzanne, Panza Kaitlyn E, Ercan-Sencicek A Gulhan, Krusong Kuakarun, Leventhal Bennett L, Ohtsu Hiroshi, Bloch Michael H, Hughes Zoë A, Krystal John H, Mayes Linda, de Araujo Ivan, Ding Yu-Shin, State Matthew W, Pittenger Christopher
Abstract excerpt
Tourette syndrome (TS) is characterized by tics, sensorimotor gating deficiencies, and abnormalities of cortico-basal ganglia circuits. A mutation in histidine decarboxylase (Hdc), the key enzyme for the biosynthesis of histamine (HA), has been implicated as a rare genetic cause. Hdc knockout mice exhibited potentiated tic-like stereotypies, recapitulating core phenomenology of TS; these were mitigated by the...
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