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Article

GABAergic inhibition of histaminergic neurons regulates active waking but not the sleep-wake switch or propofol-induced loss of consciousness.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 19 Sept 2012

Zecharia Anna Y, Yu Xiao, Götz Thomas, Ye Zhiwen, Carr David R, Wulff Peer, Bettler Bernhard, Vyssotski Alexei L, Brickley Stephen G, Franks Nicholas P, Wisden William

Abstract excerpt

The activity of histaminergic neurons in the tuberomammillary nucleus (TMN) of the hypothalamus correlates with an animal's behavioral state and maintains arousal. We examined how GABAergic inputs onto histaminergic neurons regulate this behavior. A prominent hypothesis, the "flip-flop" model, predicts that increased and sustained GABAergic drive onto these cells promotes sleep. Similarly, because of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22993424
DOI: 10.1523/JNEUROSCI.2931-12.2012
PMCID: PMC3466043

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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