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Article

Histamine-HisCl1 receptor axis regulates wake-promoting signals in Drosophila melanogaster.

PloS one - 1 Jan 2013

Oh Yangkyun, Jang Donghoon, Sonn Jun Young, Choe Joonho

Abstract excerpt

Histamine and its two receptors, histamine-gated chloride channel subunit 1 (HisCl1) and ora transientless (Ort), are known to control photoreception and temperature sensing in Drosophila. However, histamine signaling in the context of neural circuitry for sleep-wake behaviors has not yet been examined in detail. Here, we obtained mutant flies with compromised or enhanced histamine signaling and tested their...

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PMID: 23844178
DOI: 10.1371/journal.pone.0068269
PMCID: PMC3700972

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