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Article

Systematic interactome mapping of acute lymphoblastic leukemia cancer gene products reveals EXT-1 tumor suppressor as a Notch1 and FBWX7 common interactor.

BMC cancer - 26 May 2016

Daakour Sarah, Hajingabo Leon Juvenal, Kerselidou Despoina, Devresse Aurelie, Kettmann Richard, Simonis Nicolas, Dequiedt Franck, Twizere Jean-Claude

Abstract excerpt

BACKGROUND: Perturbed genotypes in cancer can now be identified by whole genome sequencing of large number of diverse tumor samples, and observed gene mutations can be used for prognosis and classification of cancer subtypes. Although mutations in a few causative genes are directly linked to key signaling pathways perturbation, a global understanding of how known cancer genes drive oncogenesis in human is...

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Source

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Identifiers

PMID: 27229929
DOI: 10.1186/s12885-016-2374-2
PMCID: PMC4882867

Genes

EXT1
NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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