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Article

The Mutational Landscape of Acute Promyelocytic Leukemia Reveals an Interacting Network of Co-Occurrences and Recurrent Mutations.

PloS one - 1 Jan 2016

Ibáñez Mariam, Carbonell-Caballero José, García-Alonso Luz, Such Esperanza, Jiménez-Almazán Jorge, Vidal Enrique, Barragán Eva, López-Pavía María, LLop Marta, Martín Iván, Gómez-Seguí Inés, Montesinos Pau, Sanz Miguel A, Dopazo Joaquín, Cervera José

Abstract excerpt

Preliminary Acute Promyelocytic Leukemia (APL) whole exome sequencing (WES) studies have identified a huge number of somatic mutations affecting more than a hundred different genes mainly in a non-recurrent manner, suggesting that APL is a heterogeneous disease with secondary relevant changes not yet defined. To extend our knowledge of subtle genetic alterations involved in APL that might cooperate with PML/RARA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26886259
DOI: 10.1371/journal.pone.0148346
PMCID: PMC4757557

Genes

IKZF1
LYN
MYCBP2
PML
PTPN11
RARA
STAG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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