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Giardia spp.-induced microbiota dysbiosis disrupts intestinal mucin glycosylation

16 Oct 2024

Abstract excerpt

Infection with the protozoan parasite Giardia duodenalis (syn. intestinalis, lamblia) has been associated with intestinal mucus disruptions and microbiota dysbiosis. The mechanisms remain incompletely understood. Mucus consists primarily of densely glycosylated mucin glycoproteins. Mucin O-glycans influence mucus barrier properties and mucin–microbe interactions and are frequently altered during disease. In this...

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PMID: 39412866
DOI: 10.1080/19490976.2024.2412676

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