Article
Genetic Polymorphisms of Transcription Factor NRF2 and of its Host Gene Sulfiredoxin (SRXN1) are Associated with Cerebrovascular Disease in a Finnish Cohort, the TAMRISK Study.
International journal of medical sciences - 1 Jan 2016
Kunnas Tarja, Määttä Kirsi, Nikkari Seppo T
Abstract excerpt
Oxidative stress is involved in the pathophysiology of many cardiovascular disorders, such as hypertension and atherosclerosis. NRF2 is the primary transcriptional regulator of several antioxidant genes, including that of sulfiredoxin (SRXN1). The association of genotypes of NRF2 and SRXN1 with cardiovascular conditions was studied in a Finnish cohort of 336 subjects with diagnosed hypertension and 480...
Topics
- Cardiovascular Diseases
- Chi-Square Distribution
- Finland
- Genotype
- Humans
- Hypertension
- NF-E2-Related Factor 2
- Oxidative Stress
- Oxidoreductases Acting on Sulfur Group Donors
- Polymorphism, Single Nucleotide
- Risk Factors