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Article

Genetic polymorphisms and protein expression of NRF2 and Sulfiredoxin predict survival outcomes in breast cancer.

Cancer research - 1 Nov 2012

Hartikainen Jaana M, Tengström Maria, Kosma Veli-Matti, Kinnula Vuokko L, Mannermaa Arto, Soini Ylermi

Abstract excerpt

NRF2 activates several protective genes, such as sulfiredoxin (SRXN1), as a response to oxidative and xenobiotic stress. Defects in NRF2 pathway may increase cancer susceptibility. In tumor cells, activation of NRF2 may lead to chemo- and radioresistance and thus affect patient outcome. Nine sing...

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Source

Identifiers

PMID: 22964583
DOI: 10.1158/0008-5472.CAN-12-1474

Genes

SRXN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22964583-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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