Article
Association of single nucleotide polymorphisms in the NRF2 promoter with vascular stiffness with aging.
PloS one - 1 Jan 2020
Shimizu Sunao, Mimura Junsei, Hasegawa Takanori, Shimizu Eigo, Imoto Seiya, Tsushima Michiko, Kasai Shuya, Yamazaki Hiromi, Ushida Yusuke, Suganuma Hiroyuki, Tomita Hirofumi, Yamamoto Masayuki, Nakaji Shigeyuki, Itoh Ken
Abstract excerpt
PURPOSE: Pulse wave velocity (PWV), an indicator of vascular stiffness, increases with age and is increasingly recognized as an independent risk factor for cardiovascular disease (CVD). Although many mechanical and chemical factors underlie the stiffness of the elastic artery, genetic risk factors related to age-dependent increases in PWV in apparently healthy people are largely unknown. The transcription factor...
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