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Article

Variation in PPP3CC Genotype Is Associated with Long-Term Recovery after Severe Brain Injury.

Journal of neurotrauma - 1 Jan 2017

Osier Nicole D, Bales James W, Pugh Bunny, Shin Samuel, Wyrobek Julie, Puccio Ava M, Okonkwo David O, Ren Dianxu, Alexander Sheila, Conley Yvette P, Dixon C Edward

Abstract excerpt

After experimental traumatic brain injury (TBI), calcineurin is upregulated; blocking calcineurin is associated with improved outcomes. In humans, variation in the calcineurin A-gamma gene (PPP3CC) has been associated with neuropsychiatric disorders, though any role in TBI recovery remains unknown. This study examines associations between PPP3CC genotype and mortality, as well as gross functional status assessed...

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Source

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Identifiers

PMID: 27225880
DOI: 10.1089/neu.2015.4343
PMCID: PMC5198144

Genes

PPP3CC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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