Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Additive composite ABCG2, SLC2A9 and SLC22A12 scores of high-risk alleles with alcohol use modulate gout risk.

Journal of human genetics - 1 Sept 2016

Tu Hung-Pin, Chung Chia-Min, Min-Shan Ko Albert, Lee Su-Shin, Lai Han-Ming, Lee Chien-Hung, Huang Chung-Ming, Liu Chiu-Shong, Ko Ying-Chin

Abstract excerpt

The aim of the present study was to evaluate the contribution of urate transporter genes and alcohol use to the risk of gout/tophi. Eight variants of ABCG2, SLC2A9, SLC22A12, SLC22A11 and SLC17A3 were genotyped in male individuals in a case-control study with 157 gout (33% tophi), 106 asymptomatic hyperuricaemia and 295 control subjects from Taiwan. The multilocus profiles of the genetic risk scores for urate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcohol Drinking
Share to ATP Binding Cassette Transporter, Subfamily G, Member 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Comorbidity

Share to Glucose Transport Proteins, Facilitative

Share to Hyperuricemia

Share to Organic Anion Transporters

Share to Organic Cation Transport Proteins

Source

Identifiers

PMID: 27225847
DOI: 10.1038/jhg.2016.57

Genes

ABCG2

Variants

rs1014290

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Additive composite ABCG2, SLC2A9 and SLC22A12 scores of high-risk alleles with alcohol use modulate gout risk.PMID 27225847Read ↗

Triglyceride-glucose index and its additive interaction with ABCG2/SLC2A9 polygenic risk score on hyperuricemia in middle age and older adults: findings from the DLCC and BHMC study.Semantic proximity Read ↗

Common dysfunctional variants of ABCG2 have stronger impact on hyperuricemia progression than typical environmental risk factors.Semantic proximity Read ↗

Synergistic effects of ABCG2 Q141K variant in combination with alcohol consumption and male sex on gout risk in a rare-event Taiwanese cohort.Semantic proximity Read ↗

Risk of gout among Taiwanese adults with ALDH-2 rs671 polymorphism according to BMI and alcohol intake.Semantic proximity Read ↗

The association between genetic polymorphisms in ABCG2 and SLC2A9 and urate: an updated systematic review and meta-analysis.Semantic proximity Read ↗

Genetic variation in the ABCG2 gene is associated with gout risk in the Chinese Han population.Semantic proximity Read ↗

Joint effects of alcohol consumption and ABCG2 Q141K on chronic tophaceous gout risk.Semantic proximity Read ↗

The haplotype of SLC2A9_rs3733591, PKD2_rs2725220 and ABCG2_rs2231142 increases the hyperuricaemia risk and alcohol, chicken and processed meat intakes and smoking interact with its risk.Semantic proximity Read ↗

Association of ABCG2 rs2231142 Allele and BMI With Hyperuricemia in an East Asian PopulationSemantic proximity Read ↗

Interaction of the GCKR and A1CF loci with alcohol consumption to influence the risk of gout.Semantic proximity Read ↗

Are polymorphisms affecting serum urate, renal urate handling and alcohol intake associated with co-morbidities in gout cases? A case-control study using data from the UK Biobank.Semantic proximity Read ↗

Associations of the ALDH2 rs671 polymorphism and alcohol intake with early-onset gout in a Chinese male cohort.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.