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Article

The serpins: nature's molecular mousetraps.

Science progress - 1 Jan 2001

Huntington J A, Carrell R W

Abstract excerpt

A special family of inhibitors, known as the serpins, has evolved an extraordinary mechanism to enable the control of the proteolytic pathways essential to life. The serpins undergo a profound change in conformation to entrap their target protease in an irreversible complex. The solving of the structure of this complex now completes a video depiction of the changes involved. The serpin, just like a mousetrap, is...

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Identifiers

PMID: 11525014
DOI: 10.3184/003685001783239032
PMCID: PMC10361183

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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