Article

The NLRP3/eIF2 axis drives cell cycle progression in acute myeloid leukemia

2021-06-25

Abstract excerpt

Aberrant activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome mediates numerous inflammatory diseases. Oncogenes can activate the NLRP3 inflammasome and thereby promote myeloproliferative neoplasia, suggesting a crucial role of NLRP3 in the malignant transformation of hematopoietic cells. Here, we show that bone marrow-derived mononuclear cells of AML patients display enhanced expression of...

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Literature Corpus work: cda22ce7-d31e-5d70-b4f7-af65702ec90d
DOI: 10.1101/2021.06.25.449862

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