Article
NLRP7, a nucleotide oligomerization domain-like receptor protein, is required for normal cytokine secretion and co-localizes with Golgi and the microtubule-organizing center.
The Journal of biological chemistry - 16 Dec 2011
Messaed Christiane, Akoury Elie, Djuric Ugljesa, Zeng Jibin, Saleh Maya, Gilbert Lucy, Seoud Muhieddine, Qureshi Salman, Slim Rima
Abstract excerpt
A hydatidiform mole (HM) is a human pregnancy with hyperproliferative placenta and abnormal embryonic development. Mutations in NLRP7, a member of the nucleotide oligomerization domain-like receptor family of proteins with roles in inflammation and apoptosis, are responsible for recurrent HMs. However, little is known about the functional role of NLRP7. Here, we demonstrate that peripheral blood mononuclear cells...
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