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Clusterin levels are increased in <scp>A</scp>lzheimer's disease and influence the regional distribution of A<b>β</b>

2 Jun 2016

Abstract excerpt

Clusterin, also known as apoJ, is a lipoprotein abundantly expressed within the CNS. It regulates Aβ fibril formation and toxicity and facilitates amyloid-β (Aβ) transport across the blood-brain barrier. Genome-wide association studies have shown variations in the clusterin gene (CLU) to influence the risk of developing sporadic Alzheimer's disease (AD). To explore whether clusterin modulates the regional...

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PMID: 27248362
DOI: 10.1111/bpa.12392

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