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Article

Autism-relevant behaviors are minimally impacted by conditional deletion of Pten in oxytocinergic neurons.

Autism research : official journal of the International Society for Autism Research - 1 Dec 2016

Clipperton-Allen Amy E, Chen Youjun, Page Damon T

Abstract excerpt

Germline heterozygous mutations in Pten (phosphatase and tensin homolog) are associated with macrocephaly and autism spectrum disorders (ASD). Pten germline heterozygous (Pten+/- ) mice approximate these mutations, and both sexes show widespread brain overgrowth and impaired social behavior. Strikingly similar behavior phenotypes have been reported in oxytocin (Oxt) and/or oxytocin receptor (OxtR) knockout mice....

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Identifiers

PMID: 27220363
DOI: 10.1002/aur.1641
PMCID: PMC6467524

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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