Gene-environment interaction between perinatal oxytocin exposure and Pten mutation shapes epigenetic reprogramming of oxytocin signaling and behavior in mice.

doi:10.1016/j.nbd.2026.107559

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Article

Gene-environment interaction between perinatal oxytocin exposure and Pten mutation shapes epigenetic reprogramming of oxytocin signaling and behavior in mice.

Neurobiology of disease - 1 Oct 2026

Bussies Parker L, Tan Zhibing, Shelestak John, Sarn Nicholas, Lee Joyce H, Sadler Tammy, Eng Charis, Louveau Antoine, DeSilva Tara M

Abstract excerpt

Synthetic oxytocin (Pitocin) is the most commonly used pharmacologic agent for induction and augmentation of labor. Beyond its uterotonic effects, oxytocin plays a critical role in neurodevelopment and social behavior. Dysregulated oxytocin signaling has been implicated in autism spectrum disorder (ASD), raising concern that perinatal exposure to exogenous oxytocin may have lasting neurodevelopmental...

Read the complete abstract on PubMed

Topics

Animals
Female
PTEN Phosphohydrolase
Oxytocin
Gene-Environment Interaction
Pregnancy

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mice

Epigenesis, Genetic

Receptors, Oxytocin

Signal Transduction

Social Behavior

Male

Prenatal Exposure Delayed Effects

Mutation

Mice, Inbred C57BL

Behavior, Animal

Autism Spectrum Disorder

Source

Open in PubMed

Identifiers

PMID: 42551658
DOI: 10.1016/j.nbd.2026.107559

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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