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Article

Oxytocin receptor knockout mice display deficits in the expression of autism-related behaviors.

Hormones and behavior - 1 Mar 2012

Pobbe Roger L H, Pearson Brandon L, Defensor Erwin B, Bolivar Valerie J, Young W Scott, Lee Heon-Jin, Blanchard D Caroline, Blanchard Robert J

Abstract excerpt

A wealth of studies has implicated oxytocin (Oxt) and its receptors (Oxtr) in the mediation of social behaviors and social memory in rodents. It has been suggested that failures in this system contribute to deficits in social interaction that characterize autism spectrum disorders (ASD). In the current analyses, we investigated the expression of autism-related behaviors in mice that lack the ability to synthesize...

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Identifiers

PMID: 22100185
DOI: 10.1016/j.yhbeh.2011.10.010
PMCID: PMC3373312

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