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The Oncogenic Functions of MASTL Kinase

23 Nov 2018

Abstract excerpt

MASTL kinase is a master regulator of mitosis, essential for ensuring that mitotic substrate phosphorylation is correctly maintained. It achieves this through the phosphorylation of alpha-endosulfine and subsequent inhibition of the tumor suppressor PP2A-B55 phosphatase. In recent years MASTL has also emerged as a novel oncogenic kinase that is upregulated in a number of cancer types, correlating with chromosome...

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PMID: 30555827
DOI: 10.3389/fcell.2018.00162

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