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Article

Subnuclear targeting of the Runx3 tumor suppressor and its epigenetic association with mitotic chromosomes

12 Nov 2008

Abstract excerpt

Runx proteins are tissue-specific transcriptional scaffolds that organize and assemble regulatory complexes at strategic sites of target gene promoters and at intranuclear foci to govern activation or repression. During interphase, fidelity of intranuclear targeting supports the biological activity of Runx1 and Runx2 proteins. Both factors regulate genes involved in cell cycle control and cell growth (e.g., rRNA...

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PMID: 19006109
DOI: 10.1002/jcp.21630

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