Article
Cultured pericytes from human brain show phenotypic and functional differences associated with differential CD90 expression.
Scientific reports - 24 May 2016
Park Thomas I-H, Feisst Vaughan, Brooks Anna E S, Rustenhoven Justin, Monzo Hector J, Feng Sheryl X, Mee Edward W, Bergin Peter S, Oldfield Robyn, Graham E Scott, Curtis Maurice A, Faull Richard L M, Dunbar P Rod, Dragunow Mike
Abstract excerpt
The human brain is a highly vascular organ in which the blood-brain barrier (BBB) tightly regulates molecules entering the brain. Pericytes are an integral cell type of the BBB, regulating vascular integrity, neuroinflammation, angiogenesis and wound repair. Despite their importance, identifying pericytes amongst other perivascular cell types and deciphering their specific role in the neurovasculature remains a...
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