A subset of cerebrovascular pericytes originates from mature macrophages in the very early phase of vascular development in CNS.

doi:10.1038/s41598-017-03994-1

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Article

A subset of cerebrovascular pericytes originates from mature macrophages in the very early phase of vascular development in CNS.

Scientific reports - 20 Jun 2017

Yamamoto Seiji, Muramatsu Masashi, Azuma Erika, Ikutani Masashi, Nagai Yoshinori, Sagara Hiroshi, Koo Bon-Nyeo, Kita Satomi, O'Donnell Erin, Osawa Tsuyoshi, Takahashi Hiroyuki, Takano Ken-Ichi, Dohmoto Mitsuko, Sugimori Michiya, Usui Isao, Watanabe Yasuhide, Hatakeyama Noboru, Iwamoto Takahiro, Komuro Issei, Takatsu Kiyoshi, Tobe Kazuyuki, Niida Shumpei, Matsuda Naoyuki, Shibuya Masabumi, Sasahara Masakiyo

Abstract excerpt

Pericytes are believed to originate from either mesenchymal or neural crest cells. It has recently been reported that pericytes play important roles in the central nervous system (CNS) by regulating blood-brain barrier homeostasis and blood flow at the capillary level. However, the origin of CNS microvascular pericytes and the mechanism of their recruitment remain unknown. Here, we show a new source of...

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PMID: 28634350
DOI: 10.1038/s41598-017-03994-1
PMCID: PMC5478595

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