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Modelling the Neurovascular Unit and the Blood-Brain Barrier with the Unique Function of Pericytes

1 Nov 2011

Abstract excerpt

The blood-brain barrier (BBB) is a dynamic cellular complex that is responsible for the maintenance of brain homeostasis. To understand the BBB's key cellular and molecular mechanisms, in vitro models combining endothelial cells and astrocytes can be used to reproduce most of the barrier's in vivo features (low paracellular permeability and the expression of specific transporters). However, these models lack...

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PMID: 22023614
DOI: 10.2174/156720211798121016

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