Article
Using Mendelian randomization to investigate a possible causal relationship between adiposity and increased bone mineral density at different skeletal sites in children.
International journal of epidemiology - 1 Oct 2016
Kemp John P, Sayers Adrian, Smith George Davey, Tobias Jonathan H, Evans David M
Abstract excerpt
BACKGROUND: Lean mass is positively associated with bone mineral density (BMD). However, the relationship between adiposity and BMD is more controversial. In particular, it is unclear if the observational association between the two reflects a causal effect of fat mass on BMD. Previous Mendelian randomization (MR) studies using variants in the FTO and MC4R genes as genetic instruments for adiposity have suggested...
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