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Article

Next-generation sequencing in systemic mastocytosis: Derivation of a mutation-augmented clinical prognostic model for survival.

American journal of hematology - 1 Sept 2016

Pardanani Animesh, Lasho Terra, Elala Yoseph, Wassie Emnet, Finke Christy, Reichard Kaaren K, Chen Dong, Hanson Curtis A, Ketterling Rhett P, Tefferi Ayalew

Abstract excerpt

In routine practice, the World Health Organization classification of systemic mastocytosis (SM) is also the de facto prognostic system; a core value is distinguishing indolent (ISM) from advanced SM (includes aggressive SM [ASM], SM with associated hematological neoplasm [SM-AHN] and mast cell leukemia [MCL]). We sequenced 27 genes in 150 SM patients to identify mutations that could be integrated into a...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27214377
DOI: 10.1002/ajh.24426

Genes

ASXL1
CBL
KIT
RUNX1
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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