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Article

Impact of somatic and germline mutations on the outcome of systemic mastocytosis

29 Oct 2018

Abstract excerpt

Abstract Systemic mastocytosis (SM) is a highly heterogeneous disease with indolent and aggressive forms, with the mechanisms leading to malignant transformation still remaining to be elucidated. Here, we investigated the presence and frequency of genetic variants in 34 SM patients with multilineal KIT D816V mutations. Initial screening was performed by targeted sequencing of 410 genes in DNA extracted from...

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PMID: 30373888
DOI: 10.1182/bloodadvances.2018020628

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