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Leukocytosis, Monocytosis, and Eosinophilia in Systemic Mastocytosis: Analysis of Phenotype, Genetics and Prognosis in 596 Patients From the GREM Registry.

The journal of allergy and clinical immunology. In practice - 1 Jan 2026

Lübke Johannes, Naumann Nicole, Dangelo Vito, Fabarius Alice, Metzgeroth Georgia, Horny Hans-Peter, Sotlar Karl, Hofmann Wolf-Karsten, Rudelius Martina, Schwaab Juliana, Reiter Andreas

Abstract excerpt

BACKGROUND: Leukocytosis, monocytosis, and eosinophilia (L/M/E) are recurrent findings in systemic mastocytosis (SM). OBJECTIVE: To investigate the prevalence of L/M/E in SM and assess their association with clinical phenotype, mutational profile, and overall survival (OS) in advanced SM (AdvSM). METHODS: Within the German Registry on Disorders of Eosinophilia and Mast Cells, 596 patients with SM (91% KIT D816V...

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Identifiers

PMID: 41005704
DOI: 10.1016/j.jaip.2025.09.018

Genes

ASXL1
KIT
SRSF2
TET2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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